The alpha-2 agonists are one of the most useful drug classes for sedation of FAS or aggressive dogs and cats because:

• A. Profound sedation can be achieved
• B. The drugs are effective when administered IM
• C. Alpha-2 agonists are reversible
• D. All of the above are true

Answer: (D)

Alpha-2 agonists are valued here because they produce reliable sedation with anxiolysis (often with some analgesia), which helps calm fearful or aggressive dogs and cats without full anesthesia. They’re particularly convenient because they can be given intramuscularly with a rapid onset, allowing effective sedation with minimal restraint. A crucial safety feature is that reversal agents exist for these drugs (for example, atipamezole reverses medetomidine/dexmedetomidine; other alpha-2 agonists have antagonists such as yohimbine or tolazoline), enabling a quick, controlled recovery if sedation is deeper than intended or if adverse effects develop. These combined properties—deep enough sedation, effective IM use, and reversibility—make this drug class especially useful for managing fearful or aggressive patients.