Which reversal agent is used for alpha-2 agonists?

• A. Yohimbine
• B. Atipamezole
• C. Naloxone
• D. Flumazenil

Answer: (B)

Reversing alpha-2 agonists requires a selective antagonist at the alpha-2 receptor to block the sedative, analgesic, and cardiovascular effects. Atipamezole fits this role best, because it specifically antagonizes alpha-2 receptors and rapidly displaces the agonist (such as dexmedetomidine, medetomidine, or xylazine), reversing sedation and restoring sympathetic tone quickly. That’s why it’s the preferred reversal agent in veterinary practice. The other drugs target different receptors or have less routine use for alpha-2 reversal: naloxone reverses opioids, flumazenil reverses benzodiazepines, and yohimbine is another alpha-2 antagonist but is less commonly used as the standard reversal in current practice.